Developmental specification of forebrain cholinergic neurons
نویسندگان
چکیده
منابع مشابه
Profiles in Basal Forebrain Non-cholinergic Neurons
2 Intrinsic Voltage Dynamics Govern the Diversity of Spontaneous Firing 3 Profiles in Basal Forebrain Non-cholinergic Neurons 4 5 6 Saak V. Ovsepian, Oliver J. Dolly and Laszlo Zaborszky 7 8 (1) Centre for Molecular and Behavioral Neuroscience, Rutgers, The State University of 9 New Jersey, 197 University Avenue, Newark, NJ 07102, USA; (2) International Centre 10 for Neurotherapeutics, Research...
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The basal forebrain (BF) plays an important role in the control of cortical activation and attention. Understanding the modulation of BF neuronal activity is a prerequisite to treat disorders of cortical activation involving BF dysfunction, such as Alzheimer's disease. Here we reveal the interaction between cholinergic neurons and cortically projecting BF GABAergic neurons using immunohistochem...
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The basal forebrain cholinergic system modulates neuronal excitability and vascular tone throughout the cerebral cortex and hippocampus. This system is severely affected in Alzheimer's disease (AD), and drug treatment to enhance cholinergic signaling is widely used as symptomatic therapy in AD. Defining the full morphologies of individual basal forebrain cholinergic neurons has, until now, been...
متن کاملCorelease of acetylcholine and GABA from cholinergic forebrain neurons
Neurotransmitter corelease is emerging as a common theme of central neuromodulatory systems. Though corelease of glutamate or GABA with acetylcholine has been reported within the cholinergic system, the full extent is unknown. To explore synaptic signaling of cholinergic forebrain neurons, we activated choline acetyltransferase expressing neurons using channelrhodopsin while recording post-syna...
متن کاملImpact of basal forebrain cholinergic inputs on basolateral amygdala neurons.
In addition to innervating the cerebral cortex, basal forebrain cholinergic (BFc) neurons send a dense projection to the basolateral nucleus of the amygdala (BLA). In this study, we investigated the effect of near physiological acetylcholine release on BLA neurons using optogenetic tools and in vitro patch-clamp recordings. Adult transgenic mice expressing cre-recombinase under the choline acet...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2017
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2016.11.007